Sepsis continues to pose a serious global health concern in spite of better treatment options. According to reports, LPS, the main component of gram-negative bacteria's outer membrane, is a strong inducer of the inflammatory response that causes inflammation in gram-negative sepsis. Crucially, LPS-induced activation of the TLR4 signaling pathway is a key factor in the pathophysiology of sepsis. Single nucleotide polymorphisms (SNPs) of the TLR4 gene in humans may be associated with a higher risk of contracting Gram-negative bacterial infections or with a quicker onset and more severe course of sepsis, according to studies. Moreover, patients with severe sepsis who have high TLR4 levels tend to have worse outcomes. <a href="https://www.creative-biolabs.com/drug-discovery/diagnostics/ivd-antibody-development-services-for-tlr4-marker.htm">TLR4 antibody</a> can be employed in this situation as a sensitive and specific marker for sepsis identification.